In reply to Pete. (l33t FS) :
Right, because harmonics in industrial power drive drive applications is so rare ...
Seems to me that the issue is not so much harmonics, but resonance and torsional deflection.
As well, we are not talking about F1 RPM, F1 packaging constraints, or F1 weight limits.
Torsional stiffness in a shaft varies as the 4th power of the OD, the Easy Button is to increase
the shaft diameter; Next most Easy Button is torsional damping.
In reply to clshore :
One of the ways that Ford pushrod engines are better than Chevy is that the distributor is driven by the timing chain end of the camshaft. Even with the constant load of the oil pump to damp the loads, Chevy timing is all over the place because the cam twists around like a wet noodle.
The unspoken reason why GM stuck the distributor on the timing cover on the LT1. It sure as heck was not for ease of service 
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