I agree with the comments that a septic system is not meant to be ignored. Pumped every 3-5 years, no nearby trees or plants to avoid roots in the system, and never put food scraps or grease into the system. Flushable wipes are NOT flushable. Same goes for absolutely anything other than toilet paper.
Issues specific to SW Florida (or anywhere in the state eventually) include the possibility of needing to pay for a sewer hookup when that becomes a requirement. Septic systems are an issue here and many will have to be phased out over time.
Due to the use of septic systems, overuse of fertilizer particularly on residential yards, farming practices, and various other causes, Florida waterways are heavily overloaded with nutrients. This has resulted in severe toxic algae overgrowth in the waterways, and I think the Port Charlotte area is one of the most severely affected.
As for wells, I've always made municipal water a non-negotiable requirement for my homes here. If you're going to be on well water, find out what was there before the house was built.
I'm lucky that I've had that policy, as one house I ruled out in a neighborhood here in Volusia county was next to a golf course. It turned out that there were multiple children with cancer in the neighborhood, as well as people in their 30s and 40s dying of Parkinson's. They never did identify the toxins.
Be sure that the land where your prospective home is located has never been used for a golf course or fern farm in particular. There's been an amazing amount of toxins dumped into the environment here in Florida, and not all of them are detectable in standard water testing. Water testing here usually will just be to rule out water borne pathogens such as fecal coliform bacteria.
They are probably not going to test for or even be able to detect some of the heavy metals, neurotoxins and carcinogens that were used heavily in certain areas. Make any previous military use of the area also a no-go. The WWII and Cold War era military bases dumped everything into the ground, plus there are neighborhoods here in Florida that have been built on live fire ranges.
I apologize for the overall tenor of this post, but I've lived here since the first Eisenhower administration. It's better that you have a chance to consider these things now.